Related Hormonal Deficiencies and Their Association with Neurodegenerative Diseases
DOI:
https://doi.org/10.22399/ijsusat.5Keywords:
Degenerative diseases, Neurodegenerative, Hormonal DeficienciesAbstract
In recent years, in general terms, worldwide birth rates have been falling and life expectancy has been rising , resulting in an increasing rate of population aging . The occurrence of this moderate decline in aging is normal , but there are dementia syndromes in which this decline is accentuated . Thus, the research will demonstrate a study involving hormonal deficiencies in general and, as the main research objective, those involving age and, also, involving the association with neurodegenerative diseases . In this perspective, we opted for bibliographical research , and to achieve this , a dialectical evaluation of the positions of competent theorists in relation to the subjects discussed will be performed , with the data being evaluated through interpretation , analysis and comparisons on the subjects worked on . Cognitive decline in old age has become a growing concern due to the pace of the increasing aging of the population and its potential deleterious effect on the quality of life of individuals . Identifying people who are more likely to suffer from cognitive decline allows for the establishment of interventions to prevent, delay or even reverse cognitive changes .
References
[1] Baddeley, A., Anderson, M. C., & Eysenck, M. W. (2011). Memory. Porto Alegre: Artmed.
[2] Abreu Filho, H. (Ed.). (2004). Comments on the Elderly Statute. Brasília: Special Secretariat for Human Rights.
[3] Dalgalarrondo, P. (2008). Psychopathology and seminology of mental disorders. Porto Alegre: Artmed.
[4] Li, R., & Singh, M. (2014). Sex differences in cognitive impairment and Alzheimer's disease. Frontiers in Aging Neuroscience, 35(3), 385–403. https://doi.org/10.1016/j.yfrne.2014.01.002
[5] Zhang, Z. (2018). The early events that initiate β-amyloid aggregation in Alzheimer's disease. Frontiers in Aging Neuroscience, 10, 359. https://doi.org/10.3389/fnagi.2018.00359
[6] Russell, N., & Grossmann, M. (2019). Mechanisms in endocrinology: Estradiol as a male hormone. European Journal of Endocrinology, 181(1), R23–R43. https://doi.org/10.1530/EJE-18-1000
[7] Schulster, M., Bernie, A. M., & Ramasamy, R. (2016). The role of estradiol in male reproductive function. Asian Journal of Andrology, 18(3), 435–440. https://doi.org/10.4103/1008-682X.173932
[8] Rasgon, N. L., Magnusson, C., Johansson, A. L., Pedersen, N. L., Elman, S., & Gatz, M. (2005). Endogenous and exogenous hormone exposure and risk of cognitive impairment in Swedish twins: A preliminary study. Psychoneuroendocrinology, 30(6), 558–567. https://doi.org/10.1016/j.psyneuen.2005.01.004
[9] Fox, M., Berzuini, C., & Knapp, L. A. (2013). Cumulative estrogen exposure, number of menstrual cycles, and Alzheimer's risk in a cohort of British women. Psychoneuroendocrinology, 38, 2973–2982. https://doi.org/10.1016/j.psyneuen.2013.08.005
[10] Morrison, J. H., & Hof, P. R. (2002). Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer’s disease. Progress in Brain Research, 136, 467–486.
[11] Nicolle, M. M., Gallagher, M., & McKinney, M. (1999). No loss of synaptic proteins in the hippocampus of aged, behaviorally impaired rats. Neurobiology of Aging, 20, 343–348.
[12] Lee, J., Duan, W., & Mattson, M. P. (2002). Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. Journal of Neurochemistry, 82, 1367–1375.
[13] Thibault, O., Hadley, R., & Landfield, P. W. (2001). Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: Relationship to impaired synaptic plasticity. Journal of Neuroscience, 21, 9744–9756.
[14] Kumar, A., & Foster, T. C. (2005). Intracellular calcium stores contribute to increased susceptibility to LTD induction during aging. Brain Research, 1031, 125–128.
[15] Ferrari, E., Casarotti, D., Muzzoni, B., Albertelli, N., Cravello, L., Fioravanti, M., Solerte, S. B., & Magri, F. (2001). Age-related changes of the adrenal secretory pattern: Possible role in pathological brain aging. Brain Research Reviews, 37, 294–300.
[16] Liu, R. Y., Zhou, J. N., Hoogendijk, W. J., Van Heerikhuize, J., Kamphorst, W., Unmehopa, U. A., Hofman, M. A., & Swaab, D. F. (2000). Decreased vasopressin gene expression in the biological clock of Alzheimer disease patients with and without depression. Journal of Neuropathology and Experimental Neurology, 59, 314–322.
[17] Skene, D. J., & Swaab, D. F. (2003). Melatonin rhythmicity: Effect of age and Alzheimer’s disease. Experimental Gerontology, 38, 199–206.
[18] Canteras, N. S., & Swanson, L. W. (1992). Projections from the ventral subiculum to the amygdala, septum, and hypothalamus: A study of anterograde PHAL tracing in the rat. Journal of Comparative Neurology, 324, 180–194.
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